The Papal Museum of the Holy House is located on the west wing of the Apostolic Palace, the building that defines on two sides the Church and which is characterized by a massive “portico” adorned with Doric order on the ground floor. This portico is overheaded by a loggia in white Istria’s rock, and with Ionic order in the upper floor. The design of the Palace is due to the pontifical architect Donato Bramante, sent by Pope Julius II in 1507 with the task to “draw many artworks”. Many distinguished architects worked on this palace: Giancristoforo Romano, Andrea Sansovino, Antonio da Sangallo the Young, Raniero Nerucci, Giovanni Boccalini and, in 18th century, Luigi Vanvitelli, who decorated the façade with a balustrade. The first floor rooms, the “Noble floor”, of the west wings of the Apostolic Palace, were once used as guestrooms, that is to say they formed an apartment reserved by the governor of the Holy House to host nobles, cardinals or princes visiting the Sanctuary. It was then used during the Kingdom of Italy to receive political and administrative ambassadors. The museum collections began to increase at the end of the 19th century, when the renewal of the Church started by the action of Giuseppe Sacconi, who aimed to bring back the lauretan temple to its original form, removed what had been done in the 16th century. Many paintings and furniture coming from the Shrine and from the Apostolic Palace were gathered and collected in the Halls of the Museum, including the ceramic apothecary vases of the spicery of the Holy House, and some frescoes detached from the lateral chapels of the Church. Various donations were added time after time, as well as the ex-voto of the Ancient Treasure of the Holy House saved from the Napoleonic requisitions of 1797 and from the theft of 1974.